Twin Phenomena of Hypertrophic Cardiomyopathy: A Reported Case Series

Zeng JT1, Zhang YA2, Ma TY1, Huang K1, Lu SJ1*, Zhong JH1* and Li JJ3*

1Department of Cardiology, Xiangya School of Medicine, Haikou Affiliated Hospital of Central South University, China
2Central Laboratory, Xiangya School of Medicine, Haikou Affiliated Hospital of Central South University, China
3Cardiometabolic Center, State Key Laboratory of Cardiovascular Diseases, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, China

^*Correspondance to: Jiang-Hua Zhong 

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Abstract:

Hypertrophic Cardiomyopathy (HCM) is a prevalent genetic cardiovascular disease, characterized by asymmetric thickening of the left ventricular wall, frequently occurring in families predisposed genetically. While HCM in twins is rare, it presents a unique opportunity to explore the disease's genetic and epigenetic underpinnings due to the phenotypic heterogeneity observed even among genetically identical individuals. This review collates and analyzes global clinical studies that focus on the twin phenomena in HCM. It delves into the genetic foundations of HCM, the impact of environmental and epigenetic factors on disease expression, and underscores the critical role of genetic screening in the early and differential diagnosis of HCM. By focusing on the twin cases in HCM, this review aims to enhance our understanding of HCM's complex genetic background, which could lead to more personalized approaches in the management and treatment of this condition, thus drawing significant interest from researchers and clinicians alike.

Keywords:

Hypertrophic cardiomyopathy; Twin; Case; Inheritance

Cite the Article:

Zeng JT, Zhang YA, Ma TY, Huang K, Lu SJ, Zhong JH, et al. Twin Phenomena of Hypertrophic Cardiomyopathy: A Reported Case Series. Ann Clin Case Rep. 2024; 9: 2640..