Primary Signet-Ring Cell and Histiocytoid Carcinoma in the Axilla: A Case Report with Clinicopathology, Immunohistology, and Genetic Analysis

Kim Y1, Choi SJ2, Kim L2, Lim SM3, Ki SH4, Lee J5, Lee MH6 and Ha H6*

1Department of Internal Medicine, Inha University Hospital, Incheon, Republic of Korea
2Department of Pathology, Inha University Hospital, Inha University college of Medicine, Republic of Korea
3Department of General Surgery, Inha University Hospital, Inha University college of Medicine, Republic of Korea
4Department of Plastic Surgery, Inha University Hospital, Inha University college of Medicine, Republic of Korea
5Department of Radiation Oncology, Inha University Hospital, Inha University college of Medicine, Republic of Korea
6Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of Korea

^*Correspondance to: Hyerim Ha 

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Abstract:

Signet-Ring Cell/Histiocytoid Carcinoma (SRCHC) is a very rare skin adnexal cancer that has been to occur mainly in the eyelid and axilla. SRCHC is characterized by composed of signet-ring cells and histiocytoid epithelial cells pathologically. We report a 55-year-old man who was diagnosed with SRCHC. A 55-year-old Korean male visited the hospital with a growing axillary mass that had appeared two years ago. Computerized tomography and positron-emission tomography showed a skin-involved mass and regional lymph node in the axilla. Signet ring cell and histiocytoid epithelial cell were found in his biopsy tissue. Immunohistology examination showed a decrease in E-cadherin, estrogen receptor/progesterone receptor negative, and androgen receptor positive. Based on the above findings, SRCHC was diagnosed. Genetic analysis using next-generation sequencing revealed mutations in PIK3CA (c263G>A, pR88Q), CDH1 frameshift (c1570_1574 del CGGAT, pR524fs), and TP53 (c329G>T, pR110L). The patient underwent surgical resection and adjuvant radiotherapy. Given the limited number of known cases, further clinicopathological and genetic analyses are needed.

Keywords:

Signet-ring cell and histiocytoid carcinoma; Axilla; Clinicopathology; Next generation sequencing

Cite the Article:

Kim Y, Choi SJ, Kim L, Lim SM, Ki SH, Lee J, et al. Primary Signet-Ring Cell and Histiocytoid Carcinoma in the Axilla: A Case Report with Clinicopathology, Immunohistology, and Genetic Analysis. Ann Clin Case Rep. 2023; 8: 2526.