Ann Clin Case Rep | Volume 7, Issue 1 | Case Report | Open Access

Hyperviscosity Syndrome Multiorgan System Failure in Multiple Myeloma

Mahmoud A1*, Rana P1,2, Beilani T3 and Ismaiel IM4

1Department of Internal Medicine, St. Joseph’s University Medical Center - New Jersey, USA
2School of Medicine, St. George’s University - Grenada, West Indies
3College of Osteopathic Medicine, Kansas City University - Kansas City, USA
4Department of Pulmonary and Critical Care, St. Luke's University Hospital - Bethlehem Campus, USA

*Correspondance to: Anas Mahmoud 

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Hyperviscosity is typically seen in patients suffering from diseases such as Waldenström macroglobulinemia or sickle cell, however, is a rare occurrence in Multiple Myeloma (MM). Here we report an unusual case of a patent with MM who originally presented septic but was discovered to be suffering from hyperviscosity syndrome. Since multiple pathologies can be found in these types of patients, they may resemble a coagulopathy or infectious etiology. It is imperative to avoid diagnostic and treatment delays to avoid morbidity and mortality by exploring serum viscosity and obtaining biopsies of any lesions that may be present when hyperviscosity syndrome is on the differential. Unfortunately, in this patient, this discovery was too late, and he continued to deteriorate. He was found to have multiorgan failure and was transferred to comfort care.


Mahmoud A, Rana P, Beilani T, Ismaiel IM. Hyperviscosity Syndrome Multiorgan System Failure in Multiple Myeloma. Ann Clin Case Rep. 2022; 7:.

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