Growth Hormone Outcomes in RSS and SGA Children: Indian Tertiary Care Study

Kochar IS, Ramachandran S and Sethi A

Department of Pediatric and Adolescent Endocrinology, Indraprashta Apollo Hospital, India

^*Correspondance to: Kochar IS 

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Abstract:

Objectives: The aim of the study was to evaluate the efficacy of growth hormone in improving the predicted adult height in children with RSS and SGA in the Indian population.Method: A retrospective study of 56 children with RSS and SGA with short stature, who had taken rGH for duration of minimum 12 months were included. Their pretreatment and post treatment height and predicted height were evaluated.Results: The pre-treatment mean height was -2.618 SDS which improved to -0.010 SDS after one year of treatment. The difference between the Z score of height and weight, pre-treatment and posttreatment were statistically significant (<0.001).Conclusion: A significant height improvement occurred in both RSS and SGA children after 1year of GH treatment. There were no significant side effects noted in during this period. Children initiated at age less than 8 yrs fared marginally better than when started at a later age group.What is known• Children born small for gestation (SGA) are known to have short stature.• Etiopathogenesis for which is extremely heterogeneous, attributed to multiple genetic factors, environmental, maternal nutrition and health, drugs, infections.• The SGA children who are below -2 SDS at 4 yrs of age are highly unlikely to catch up.What this study adds• Indicating benefit of growth hormone therapy in short stature in children with RSS and SGA.• This is the first Indian study of children with RSS and SGA with statistically significant height benefits with growth hormone.• Children initiated at age less than 8 yrs fared marginally better than when started at a later age group.

Keywords:

Indian RSS; SGA; Short stature; Growth hormone

Cite the Article:

Kochar IS, Ramachandran S, Sethi A. Growth Hormone Outcomes in RSS and SGA Children: Indian Tertiary Care Study. Ann Clin Case Rep. 2018; 3: 1570.