Non-Hodgkin Lymphoma Simulating Carcinoma of the Vulvar Region: Report of Two Cases

Duenas Daniela, Enriquez Daniel, Taxa Luis, Webb Patricia, Montes Jaime and Barrionuevo Carlos

Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Peru
Department of Oncology, Instituto Nacional de Enfermedades Neoplásicas, Peru

^*Correspondance to: Duenas Daniela 

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Abstract:

Two cases of primary non-Hodgkin lymphoma of the vulva are reported. The first one corresponded to an 82-year old woman who showed a 6-cm vulvar injury with a multinodular appearance, whose pathological diagnosis was diffuse large-cell lymphoma B, germinal center B-cell type. She received R-MiniCHOP treatment for three months with partial response. The patient did not return for clinical monitoring in the end.The second case corresponded to a 35-year old woman showing an extensive vulvar ulcerated injury of 10 cm with pathological diagnosis of extranodal NK/T-cell lymphoma, nasal type with T-cell cytotoxic phenotype (EBER+), with CD56 expression and loss of CD8 expression. The T phenotype was determined by the study of genetic rearrangements for the T-cell receptor, which was monoclonal. The patient received the SMILE and GELOX treatments with low response and disease progression.Differential diagnosis is discussed, and the literature is reviewed regarding non-Hodgkin's lymphomas of the female genital tract.

Keywords:

Vulvar region; Diffuse large B-cell lymphoma; Extranodal NK/T-cell; Nasal type; Non-Hodgkin lymphoma; EBER

Cite the Article:

Daniela D, Daniel E, Luis T, Patricia W, Jaime M, Carlos B. Non-Hodgkin Lymphoma Simulating Carcinoma of the Vulvar Region: Report of Two Cases. Ann Clin Case Rep. 2018; 3: 1547.