Journal Basic Info
- Impact Factor: 1.809**
- H-Index: 6
- ISSN: 2474-1655
- DOI: 10.25107/2474-1655
Major Scope
- Genetics
- Transplantation Medicine
- Gastroenterology
- Oncology Cases
- Orthopedics & Rheumatology
- Molecular Biology
- Pulmonary Medicine
- Emergency Medicine and Critical Care
Abstract
Citation: Ann Clin Case Rep. 2016;1(1):1061.DOI: 10.25107/2474-1655.1061
Podocytic Infolding Glomerulopathy: Pathological Entity or a Distinct Disease Process
Adil Jadoon, Paul Killen and Puneet Garg
Department of Nephrology, University of Michigan, USA
Departement of Pathology, University of Michigan, USA
*Correspondance to: Puneet Garg
PDF Full Text Case Report | Open Access
Abstract:
We describe a 32-year-old pregnant female with a very distinctive glomerular morphology. She presented with increasing proteinuria in her third trimester and carried a pre-existing diagnosis of systemic lupus erythematosus (SLE). Renal biopsy showed diffusely thickened capillary loops suggestive of class V membranous lupus nephritis. However the immunofluorescence was negative and on electron microscopy the glomerular basement membrane (GBM) was diffusely thickened containing numerous cytoplasmic processes or projections that appear to extend from the podocytes and the endothelial cells, which in some locations appear to extend across the full thickness of the GBM. This unique morphology has been exclusively described in patients from Japan and labeled as Podocytic Infolding Glomerulopathy (PIG). The clinicopathological significance of podocyte infolding however has not been fully ascertained and it is unclear if PIG is a morphological entity or a distinct glomerular disease.
Keywords:
Podocytic Infolding Glomerulopathy (PIG); Proteinuria; Glomerular disease
Cite the Article:
Jadoon A, Killen P, Garg P. Podocytic Infolding Glomerulopathy: Pathological Entity or a Distinct Disease Process. Ann Clin Case Rep. 2016; 1: 1061.